Rockefeller University
Appointed in 2010
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Rockefeller University
Appointed in 2010
Yale University
Appointed in 1966
Massachusetts Institute of Technology
Appointed in 1971
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Massachusetts Institute of Technology
Appointed in 1971
California Institute of Technology
Appointed in 1978
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California Institute of Technology
Appointed in 1978
Stanford University
Appointed in 2018
Brain circuits and the neuronal cell types that form them are not static over evolutionary time. Rather, they cause and reflect the changing repertoire of animal behavior. How circuits and cell types change from their ancestral state to support novel behaviors during evolution, therefore, gives us important clues as to their current function. In my project, I will investigate the interaction between the cerebellum and the rest of the brain from this evolutionary angle by studying the progressive expansion and elaboration of the deep cerebellar nuclei, the output pathway of the cerebellum. I will profile transcriptional and protectional cell types of the DCN across species to probe changes in the DCN over deep evolutionary time. I will then integrate this dataset with developmental trajectories of the identified cell types in mouse, to provide mechanistic insight into how brain regions specialize on the level of single cells and circuit wiring to support new functions over the course of evolution.
Harvard University
Appointed in 1997
Yale University
Appointed in 1972
Harvard University Medical School
Appointed in 1993
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Harvard University Medical School
Appointed in 1993
Universite de Geneve, Switzerland
Appointed in 1963
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Universite de Geneve, Switzerland
Appointed in 1963
University of Pennsylvania
Appointed in 2006
Albert Einstein College of Medicine
Appointed in 1963
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Albert Einstein College of Medicine
Appointed in 1963
MRC Center, University Medical School, England
Appointed in 1981
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MRC Center, University Medical School, England
Appointed in 1981
Harvard University
Appointed in 1991
Ludwig Institute for Cancer Research
Appointed in 2012
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Ludwig Institute for Cancer Research
Appointed in 2012
Harvard University Medical School
Appointed in 2001
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Harvard University Medical School
Appointed in 2001
Whitehead Institute for Biomedical Research
Appointed in 1987
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Whitehead Institute for Biomedical Research
Appointed in 1987
University of California, Berkeley
Appointed in 1999
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University of California, Berkeley
Appointed in 1999
Boston Children's Hospital
Appointed in 2003
Johns Hopkins University
Appointed in 2007
Salk Institute for Biological Studies
Appointed in 2008
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Salk Institute for Biological Studies
Appointed in 2008
In the lab of Andrew Dillin, I study the mechanism of proteotoxicity in age-onset neurodegenerative diseases such as Alzheimer¬ís and Huntington¬ís. To better understand how protein homeostasis plays a role in these diseases, I use animal model systems ¬ó such as c. elegans and mice ¬ó that express toxic proteins including the amyloid beta peptide (Alzheimer’s) or poly-glutamate protein (Huntington’s).
I was born in Seoul, Korea. My desire to become a  good scientist outweighed anxiety over separating from my family, so I moved to the U.S, obtaining my PhD in biochemistry at the University of Texas Southwest Medical Center. There, I studied the mechanism of cell death and apoptosis, in particularly in various cancer cells. For my postdoc career, I wanted to try new systems to learn more of biology and use my biochemistry expertise. I chose a genetics lab where I can work with live animals and develop a better understanding of pathology in animal model systems, rather than just in groups of cells. I am hopeful that my basic science findings can turn into therapeutic tools. Outside of work, I play piano and paint, and enjoy walking my little dog on the beautiful San Diego beach.
MRC Center, University Medical School, England
Appointed in 1978
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MRC Center, University Medical School, England
Appointed in 1978
University of California, San Francisco
Appointed in 1991
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University of California, San Francisco
Appointed in 1991
MRC Center, University Medical School, England /
Purdue University
Appointed in 1968
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MRC Center, University Medical School, England / Purdue University
Appointed in 1968
Massachusetts Institute of Technology
Appointed in 1982
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Massachusetts Institute of Technology
Appointed in 1982
University of California, Berkeley /
Brandeis University
Appointed in 1961
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University of California, Berkeley / Brandeis University
Appointed in 1961
University of California, San Francisco
Appointed in 1987
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University of California, San Francisco
Appointed in 1987
University of California, San Francisco
Appointed in 2010
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University of California, San Francisco
Appointed in 2010
Salk Institute for Biological Studies
Appointed in 1971
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Salk Institute for Biological Studies
Appointed in 1971
Karolinska Institutet, Sweden
Appointed in 1962
Stanford University
Appointed in 1996
Sidney Farber Cancer Center
Appointed in 1975
Salk Institute for Biological Studies
Appointed in 1990
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Salk Institute for Biological Studies
Appointed in 1990
Stanford University
Appointed in 1984
Columbia University
Appointed in 2003
University of Chicago
Appointed in 1976
Fred Hutchinson Cancer Center
Appointed in 1998
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Fred Hutchinson Cancer Center
Appointed in 1998
University of California, Berkeley
Appointed in 1986
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University of California, Berkeley
Appointed in 1986
University of California, San Francisco
Appointed in 1985
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University of California, San Francisco
Appointed in 1985
Yale University
Appointed in 2019
Purdue University
Appointed in 1992
Whitehead Institute /
Massachusetts Institute of Technology
Appointed in 1994
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Whitehead Institute / Massachusetts Institute of Technology
Appointed in 1994
University of California, San Francisco
Appointed in 2009
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University of California, San Francisco
Appointed in 2009
I am studying genetic determinants of non-genetic variability, or ¬noise,¬î in gene expression using the yeast Saccharomyces cerevisiae.
I started college fully intending to become a physician. However, an excellent first-year interdisciplinary course exposed me to the excitement of research science, and demonstrated the power/utility of using tools from one discipline to study problems in another. I pursued a degree in physics, with the intention of applying the quantitative tools and techniques that I had learned to study biology.
My graduate studies were supervised by both Pam Silver, a molecular and cellular biologist, and Fritz Roth, a statistician and computational biologist. Their joint tutelage allowed me not only to learn fundamental molecular biology and genomics, but also how to analyze data I generated in high-throughput and computational studies. My post-doctoral research on noise in gene expression provides another opportunity to apply mathematical and computational techniques to high-throughput datasets that I am collecting myself. I hope that these studies will provide new insight into problems as fundamental.
Rockefeller University
Appointed in 1992
Massachusetts Institute of Technology
Appointed in 1984
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Massachusetts Institute of Technology
Appointed in 1984
Stanford University
Appointed in 1971
Johns Hopkins University
Appointed in 1988
Fred Hutchinson Cancer Center
Appointed in 1990
University of California, Berkeley
Appointed in 1991
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University of California, Berkeley
Appointed in 1991
University of California, San Francisco
Appointed in 2007
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University of California, San Francisco
Appointed in 2007
Fred Hutchinson Cancer Center
Appointed in 2002
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Fred Hutchinson Cancer Center
Appointed in 2002
Harvard University
Appointed in 1978