University of Chicago
Appointed in 1998
Sidney Farber Cancer Center
Appointed in 1977
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Sidney Farber Cancer Center
Appointed in 1977
National Cancer Institute
Appointed in 1988
California Institute of Technology
Appointed in 1972
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California Institute of Technology
Appointed in 1972
Memorial Sloan-Kettering Cancer Center
Appointed in 2018
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Memorial Sloan-Kettering Cancer Center
Appointed in 2018
Hemizygous deletions of ribosomal protein genes (RPGs) are recurrently found across human cancers, yet their role in tumorigenesis is poorly understood. Here, I propose to systematically investigate the function of RPG hemizygosity in cancer, using hepatocellular carcinoma (HCC) as a model, by exploring two specific hypotheses. First, based on genomic data from HCC and other tumors, and emerging biochemical evidence for mRNA-specific translational control by individual RPs, I hypothesize that RPGs act as haploinsufficient tumor suppressor genes by selectively altering the translation of oncogenic and/or tumor-suppressive mRNAs. I will assess the contribution of RPG hemizygosity to tumor initiation, progression and maintenance, and analyze its impact on mRNA translation. Second, given that RPG deletions are almost invariably hemizygous and strongly associate with loss of the p53 tumor suppressor gene, I hypothesize that RPG hemizygosity renders cancer cells more vulnerable to perturbations of ribosome homeostasis. I will examine the effects of p53 restoration and further RPG depletion in RPG hemizygous cells, and perform a ribosome homeostasis-focused screen for RPG hemizygosity-specific tumor dependencies. Together, the proposed studies may provide an explanation for the striking patterns of RPG loss in human cancer, with potential broad implications for both fundamental biology and cancer treatment.
Whitehead Institute for Biomedical Research
Appointed in 2004
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Whitehead Institute for Biomedical Research
Appointed in 2004
University of Colorado, Boulder
Appointed in 1995
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University of Colorado, Boulder
Appointed in 1995
Massachusetts General Hospital
Appointed in 1977
Princeton University
Appointed in 1993
Oregon Health and Science University
Appointed in 2024
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Oregon Health and Science University
Appointed in 2024
California Institute of Technology
Appointed in 2002
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California Institute of Technology
Appointed in 2002
Cornell University
Appointed in 1966
Cornell University
Appointed in 1966
Columbia University
Appointed in 1992
University of Alberta, Canada
Appointed in 1980
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University of Alberta, Canada
Appointed in 1980
Stanford University
Appointed in 1986
Johns Hopkins University
Appointed in 1972
Massachusetts Institute of Technology
Appointed in 2008
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Massachusetts Institute of Technology
Appointed in 2008
Massachusetts Institute of Technology
Appointed in 1974
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Massachusetts Institute of Technology
Appointed in 1974
Massachusetts Institute of Technology
Appointed in 1994
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Massachusetts Institute of Technology
Appointed in 1994
Tufts University School of Medicine
Appointed in 2000
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Tufts University School of Medicine
Appointed in 2000
University of Minnesota
Appointed in 2023
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University of Minnesota
Appointed in 2023
The human pathogen Candida albicans’ genome varies substantially between clinical isolates, yet it is currently unknown how this variation affects infection. Since many genetic variants are located in gene regulatory sequences, Dr. Petra Vande Zande predicts that there is substantial divergence in gene-regulatory networks between different C. albicans isolates that modifies their fitness. Dr. Vande Zande will use gene expression data from different isolates to model gene regulatory networks and identify key differences that impact fitness. Vande Zande will conduct these experiments in Dr. Anna Selmecki’s lab at the University of Minnesota. This research will provide direct insight into genetic differences that impact C. albicans infections. It may also provide clues into other genetically diverse systems with differences in gene-regulatory networks, including human cancers.
As a graduate student in Dr. Patricia Wittkopp’s lab at the University of Michigan, Vande Zande studied gene expression in the context of adaptive evolution. In particular, Dr. Vande Zande discovered that mutations affecting a gene’s expression from a distance are more pleiotropic and more detrimental to fitness than mutations occurring proximally to the gene of interest. With her experience in the evolution of gene expression, Dr. Vande Zande is now interested in understanding divergence in gene-regulatory networks between different clinical isolates of yeast infections.
Harvard University
Appointed in 2003
Jackson Laboratory
Appointed in 2019
Diffuse glioma is the most common primary brain tumor in adults and is characterized by a poor prognosis and near universal recurrence following therapy. Given the poor response rate to the current standard-of-care, there is an active interest in applying immunotherapy to treat this disease. However, progress on this front has been limited, due in part to limited knowledge of how the immune system interacts with glioma to influence the tumor’s evolution. My work focuses on how cells of the immune system and accompanying microenvironment interact with malignant cells to influence the developmental trajectory of diffuse glioma. By integrating multi-omic bulk and single-cell datasets from pre- and post-treatment tumors, I aim to develop a better understanding of how gliomas evade the immune response and how the standard-of-care alters these processes. Results from this work can provide insights into how to shape disease progression and enable the sensitization of the gliomas to subsequent treatment approaches.
Massachusetts Institute of Technology
Appointed in 1971
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Massachusetts Institute of Technology
Appointed in 1971
Carnegie Institute for Science
Appointed in 1989
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Carnegie Institute for Science
Appointed in 1989
Harvard University
Appointed in 2023
Cells detect and transform specific external stimuli into precise biochemical functions in a process termed signal transduction. Sensory systems are one example of signal transduction. Dr. Pablo Villar will investigate a unique sensory system: octopus chemotactile receptors that mediate contact-dependent aquatic chemosensation. Dr. Villar will use single-cell sequencing, cryo-EM, and physiology to investigate the molecular logic of receptor expression, complex formation, and physiological function in cephalopods. These experiments will be conducted in Dr. Nicholas Bellono’s lab at Harvard University. Villar’s studies will reveal general principles for the evolutionary fine tuning of signal transduction and help connect adaptations in protein structure with octopus behavior.
As a graduate student in Dr. Ricardo Araneda’s lab at the University of Maryland, Villar examined how neuromodulatory brain regions regulate circuits that process sensory information. Specifically, Dr. Villar showed that the basal forebrain activates shortly after the onset of a sensory stimuli, and in a stimulus-specific manner. With this experience in neuroscience and sensory stimuli, Villar will now examine the signal transduction of stimuli at a molecular level in cephalopods.
Stanford University
Appointed in 1976
Salk Institute for Biological Studies
Appointed in 1976
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Salk Institute for Biological Studies
Appointed in 1976
Massachusetts Institute of Technology
Appointed in 2001
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Massachusetts Institute of Technology
Appointed in 2001
Harvard University
Appointed in 1989
Harvard University Medical School
Appointed in 2001
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Harvard University Medical School
Appointed in 2001
University of Washington
Appointed in 2010
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University of Washington
Appointed in 2010
I am interested in how cells recognize and respond to viral pathogens through detection of viral nucleic acids. My research focuses on understanding innate immune pathways involved in cell intrinsic cytosolic DNA detection and coordination of an inducible antiviral response, and how dysregulation of these pathways leads to autoimmune disease.
I grew up on a California farm, surrounded by the natural world, with parents who continually nurtured my interest in it. This experience, coupled with having mentors who allowed me the freedom to follow my interests in their laboratories, have guided my development as a scientist. Freedom to direct my own research has been a tremendous gift, and I am fortunate to be in a truly collaborative research environment. By moving to Seattle I  became part of an outstanding research institute, and have also been able to pursue nonacademic interests. I have been on nationally-ranked college and club ultimate frisbee teams,  currently help coach the women’s ultimate frisbee team at the University of Washington, and compete as a competitive curler. My experiences have created many awesome friendships and helped me develop discipline, determination and leadership skills, while balancing my life as a research scientist.
Harvard University Medical School
Appointed in 2002
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Harvard University Medical School
Appointed in 2002
Columbia University
Appointed in 2008
Harvard University
Appointed in 2013
Many bacteria form complex multicellular communities known as biofilms. In these communities, cells are encased in a self-produced matrix that shield bacteria from diverse environmental stresses, antimicrobial agents, and host immune systems. Biofilms impact many arenas, including human health, ecology, and agriculture. Due to the importance and ubiquity of biofilms, there is increased interest in investigating the molecular mechanisms underlying the formation and maintenance of these communities. The soil bacterium Bacillus subtilis forms multicellular communities on the roots of some plants, including tomatoes, resulting in increased plant growth. My research examines how environmental signals are sensed by B. subtilis, initiating the biofilm program.
New York University
Appointed in 1962
Duke University
Appointed in 1991
Yale University
Appointed in 1950
Harvard University Medical School /
MRC Center, University Medical School, England
Appointed in 1977
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Harvard University Medical School / MRC Center, University Medical School, England
Appointed in 1977
University of California, San Francisco
Appointed in 2021
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University of California, San Francisco
Appointed in 2021
New experiences elicit novel patterns of neural activity, prompting changes in gene expression that underlie learning. However, most studies of human brain evolution focus on species differences in baseline gene expression. Activity-dependent enhancers that control neuronal gene expression could represent an unexplored substrate for the evolution of human cognitive specializations. To examine the evolution of the activity-regulated genome in the human lineage, I will utilize primary neurons from human and macaque as well as induced pluripotent stem cell-derived neurons from human and chimpanzee to create cortical circuits in vitro and stimulate activity with physiological paradigms. I will measure coordinated changes in chromatin accessibility and gene expression in single cells to discover human-divergent neuronal activity-regulated elements (hDAREs). A CRISPRi screen will allow me to test hDARES to determine which are human-specific activity-dependent enhancers. To begin to investigate the consequences of evolutionary alterations for brain plasticity, I will model a human-specific deletion of a candidate activity-dependent enhancer regulating a gene with known roles in restricting spine growth in mice. Utilizing in vivo imaging to measure synapse formation during motor learning, I will test the hypothesis that activity-dependent expression of this gene, conserved between mice and chimpanzee, may inhibit learning-induced synapse formation and that the human-specific deletion may relieve this plasticity brake. Combining evolutionary genetics and systems neuroscience approaches will lay the groundwork for exploring this new dimension of human brain evolution.
Johns Hopkins University
Appointed in 1964
Rockefeller University
Appointed in 2015
My research interest is to understand the epigenetic mechanisms that drive cancer development. With a focus on a few newly discovered histone posttranslational modifications, I am currently studying their functional roles and mechanisms in cellular differentiation and oncogenesis._x000D_
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I spent my first 18 years in Hainan, a beautiful island located in the South China Sea before I moved to Beijing where I received B.S. degree in Biology from Tsinghua University. Initial exposure to scientific research at Tsinghua got me fascinated about science and promoted me to pursue graduate studies at Princeton University, where, in Dr. Yibin Kangs laboratory, I investigated the genetic causes underlying cancer initiation and metastasis. Appreciating that the interplay between genetic and epigenetic regulations is important in cancer development, I joined the laboratory of Dr. David Allis as a postdoc fellow where I continue studies in cancer research with a different focus on epigenetic causes of cancer. Outside of the lab, I enjoy the outdoors, spending time with family and friends, and trying delicious food.
Massachusetts Institute of Technology
Appointed in 1980
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Massachusetts Institute of Technology
Appointed in 1980
University of California, San Diego
Appointed in 2009
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University of California, San Diego
Appointed in 2009
Current research:  I am interested in dissecting the genetic basis of adult axon regeneration in the model organism C. elegans.
My first sixteen years were spent happily in a small town in southeastern China. I didn’t have much experience in biological sciences until I became an biology major at Tsinghua University. In a neuroscience course, a professor introduced to us the fantastic structure of neurons and the intriguing molecular mechanisms underlying how neurons encode external information and learn. From that moment, I was entranced by this field, and chose it as my career path. I came to Michael Ehlers’s lab at Duke University to study the molecular mechanisms of long term plasticity in hippocampal neurons. There, I discovered that an unconventional actin motor is a critical LTP-mediating player. Subsequently, I joined Yishi Jin’s lab as a postdoctoral researcher to explore the genetic mechanisms of adult axon regeneration in C. elegans. Outside the lab, I am a super soccer fan and love fresh-water fishing. My dreams are to watch a Derby game between FC Barcelona and Real Madrid at Camp Nou and to catch a 20-pound large-mouth bass.
Harvard University
Appointed in 2012
My current research in Professor Xiaowei Zhuang’s lab at Harvard University focuses on the development and application of super-resolution light microscopy techniques to the study of chromatin organization. In particular, I am interested in the spatial organization of DNA in compact chromatin domains during the interphase.
My graduate research, co-advised by Professor Ned Wingreen and Professor Joshua Shaevitz at Princeton University, presented a series of discoveries regarding the physical properties, dynamics, and organization of the bacterial cytoskeleton and cell wall, including: 1) the mechanical contribution of bacterial cytoskeleton to cellular integrity; 2) the motion of bacterial cytoskeleton driven by cell wall synthesis; 3) the chiral organization and growth dynamics of cell wall in rod-shaped bacteria, derived from the spatial pattern of cytoskeleton; and 4) a possible mechanism for different cytoskeleton components to self-organize into distinct spatial patterns. My dissertation won the 2011 Award for Outstanding Doctoral Thesis Research in Biological Physics from American Physical Society.
University of California, San Francisco
Appointed in 2014
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University of California, San Francisco
Appointed in 2014
During mitosis, the position of the spindle determines the size, the relative orientation and the developmental fate of daughter cells. The spindle is positioned by a pulling force generated by cortically localized dynein and exerted on astral microtubules that are connected to the spindle poles. Dynein is anchored to the cell cortex by the protein NuMA and activated to pull on the end of microtubule, the mechanism of which remains unknown. To investigate this, we will first systematically define and characterize the interaction between NuMA and dynein using purified components. Next we will reconstitute the microtubule end capturing and pulling force generation activities of dynein using a microfabricated barrier based system, in which the regulation of dynein by NuMA will be investigated. In addition, we will determine the crystal structure of the complex of NuMA-dynein binding regions to reveal the structural basis for their interactions. Finally, the overall structure of full-length NuMA will be examined using electron microscope and the functional significance of NuMA oligomerization will be determined. Together our proposed study will provide a mechanistic understanding of how dynein is recruited and activated by NuMA to generate cortical pulling force for mitotic spindle positioning.
Harvard University
Appointed in 2015
Translation mediates the flow of genetic information encoded in mRNAs to proteins and can be regulated by many factors, contributing an essential part to the cellular gene expression regulation program. To understand how translation are influenced by various factors such as extracellular stimuli, cell metabolic states, subcellular localizations and so on, a method that could reveal the timing, location and level of translation activity on a defined single mRNA transcript in living cells would be invaluable. My research focuses on the development of a fluorescence imaging based method to study translation on a single mRNA transcript in living cells. I am going to use this method to study translation initiation and elongation under different conditions and at different subcellular compartments, such as neuronal dendrites and axons, to obtain previously unavailable information of translation dynamics.
Massachusetts Institute of Technology
Appointed in 2016
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Massachusetts Institute of Technology
Appointed in 2016
University of Glasgow, Scotland
Appointed in 1961
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University of Glasgow, Scotland
Appointed in 1961
Max-Planck Institute
Appointed in 1969